NOT KNOWN DETAILS ABOUT LDN-27219 PRECLINICAL RESEARCH

A single especially fascinating compound is LDN-27219. While most tTG inhibitors are designed to bind to the protein crosslinking Lively internet site, LDN-27219 as an alternative binds towards the nucleotide binding pocket of your enzyme when it is actually in its shut-state conformation, and stabilizes that conformation to circumvent crosslinking